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Secondary surgical resection for patients with recurrent uterine leiomyosarcoma.


ABSTRACT: OBJECTIVES:To assess outcomes after secondary surgical resection in patients with recurrent uterine leiomyosarcoma (uLMS). METHODS:We retrospectively identified all patients who had no evidence of disease after initial surgery for uLMS, who underwent surgery for a first recurrence at our institution between 1/1991 and 10/2013. We excluded patients who received any therapy for recurrence prior to secondary resection, and patients who underwent surgery soon after morcellation [of presumed benign fibroids] showed widespread disease. Overall survival (OS) was determined from time of first recurrence to death or last follow-up. RESULTS:We identified 62 patients: 29 with abdominal/pelvic recurrence only, 30 with lung recurrence only, 3 with both. Median time to first recurrence was 18?months (95% CI: 13.3-23.3): 15.8?months (95% CI: 13.0-18.6) abdominal/pelvic recurrence; 24.1?months (95% CI: 14.5-33.7) lung-only recurrence (p?=?0.03). Median OS was 37.7?months (95% CI: 25.9-49.6) abdominal/pelvic recurrence; 78.1?months (95% CI: 44.8-11.4) lung recurrence (p?=?0.02). Complete gross resection (CGR) was achieved in 58 cases (93%), with gross residual ?1?cm in 2 (3.5%) and >1?cm in 2 (3.5%). Median OS based on residual disease was 54.1?months (95% CI: 24.9-83.3), 38.7?months (95% CI: NE), 1.7?months (95% CI: NE), respectively (p?

SUBMITTER: Cybulska P 

PROVIDER: S-EPMC6650305 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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<h4>Objectives</h4>To assess outcomes after secondary surgical resection in patients with recurrent uterine leiomyosarcoma (uLMS).<h4>Methods</h4>We retrospectively identified all patients who had no evidence of disease after initial surgery for uLMS, who underwent surgery for a first recurrence at our institution between 1/1991 and 10/2013. We excluded patients who received any therapy for recurrence prior to secondary resection, and patients who underwent surgery soon after morcellation [of pr  ...[more]

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