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Multi-component heteroarene couplings via polarity-reversed radical cascades.

ABSTRACT: A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C-C as well as C-N, C-P, and C-Rf bond formation.

SUBMITTER: Lear JM

PROVIDER: S-EPMC6650346 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Multi-component heteroarene couplings via polarity-reversed radical cascades.

Lear Jeremy M JM Buquoi J Quentin JQ Gu Xin X Pan Kui K Mustafa Darsheed N DN Nagib David A DA

Chemical communications (Cambridge, England) 20190701 60

A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C-C as well as C-N, C-P, and C-Rf bond formation. ...[more]

PMID: 31134975

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