Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition.
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SUBMITTER: Kawasaki H
PROVIDER: S-EPMC6650393 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition.
Kawasaki Hiroshi H Soma Natsumi N Kretsinger Robert H RH
Scientific reports 20190723 1
Calmodulin is a calcium binding protein with two lobes, N-lobe and C-lobe, which evolved from duplication and fusion of a single precursor lobe of a pair of EF-hand. These two lobes of calmodulin show subtle differences in calcium binding and target recognition; these are important for the functions of calmodulin. Since the structures, especially main chain conformations, of two EF-lobes in holo-form are quite similar; this is a good example to evaluate the effect of side chains for structural d ...[more]
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