Ontology highlight
ABSTRACT:
SUBMITTER: Lee YR
PROVIDER: S-EPMC6651529 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20190628 13
Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced acetylation. While APE1/Ref-1 targeting was not affected by inhibition of the endoplasmic reticulum/Golgi-dependent secretion, its secretion was reduced by inhibitors of ATP-binding ca ...[more]