Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC6652023 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190628 13
To explore the molecular mechanisms of BAY R3401, four types of novel photoaffinity probes bearing different secondary tags were synthesized. Their potency for glycogenolysis was evaluated in primary human liver HL-7702 cells and HepG2 cells. Probe 2d showed the best activity in primary human liver HL-7702 cells and HepG2 cells, with IC<sub>50</sub> values of 4.45 μM and 28.49 μM, respectively. Likewise, probe 5d showed IC<sub>50</sub> values of 6.46 μM in primary human liver HL-7702 cells and 1 ...[more]