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Improving Estimates of Compensatory cis-trans Regulatory Divergence.

ABSTRACT: Interspecific hybrids have played a key role in research on gene expression regulation. A growing number of studies have measured genome-wide allele-specific expression in hybrids and observed that cis-regulatory changes often oppose trans-acting changes affecting the same genes, suggesting stabilizing selection for compensatory changes. However, the most common method for estimating these effects is biased, producing artifactual patterns of compensatory evolution. Here I introduce a simple modification leveraging biological replicates that ameliorates the bias.

SUBMITTER: Fraser HB

PROVIDER: S-EPMC6652221 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Improving Estimates of Compensatory cis-trans Regulatory Divergence.

Fraser Hunter B HB

Trends in genetics : TIG 20180927 1

Interspecific hybrids have played a key role in research on gene expression regulation. A growing number of studies have measured genome-wide allele-specific expression in hybrids and observed that cis-regulatory changes often oppose trans-acting changes affecting the same genes, suggesting stabilizing selection for compensatory changes. However, the most common method for estimating these effects is biased, producing artifactual patterns of compensatory evolution. Here I introduce a simple modi ...[more]

PMID: 30270122

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