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Long non-coding RNAs in the spinal cord injury: Novel spotlight.


ABSTRACT: Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non-coding RNAs (lncRNAs) are abundant in the brain and might play critical roles in several nervous system disorders. At the cellular level, lncRNAs have been shown to regulate the expression of protein-coding RNAs and hence participate in neuronal death, demyelination and glia activation. Notably, SCI is characterized by these biological processes, suggesting that lncRNAs could be novel modulators in the pathogenesis of SCI. This review describes recent progresses in the lncRNA transcriptome analyses and their molecular functions in regulating SCI progression.

SUBMITTER: Li Z 

PROVIDER: S-EPMC6653026 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Long non-coding RNAs in the spinal cord injury: Novel spotlight.

Li Zheng Z   Ho Idy H T IHT   Li Xingye X   Xu Derong D   Wu William K K WKK   Wu William K K WKK   Chan Matthew T V MTV   Li Shugang S   Liu Xiaodong X  

Journal of cellular and molecular medicine 20190529 8


Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non-coding RNAs (lncRNAs) are abundant in th  ...[more]

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