Dataset Information

Inflammatory Proteins Predict Change in Depressive Symptoms in Male and Female Adolescents.

ABSTRACT: Inflammation has been implicated in depressive symptoms, but few studies use longitudinal designs with adolescents. Furthermore, the extant literature has yielded inconsistent results. Blood was collected from a community sample of 201 adolescents (109 female, ages 12.3-20.0) and analyzed for inflammatory proteins. Up to five follow-up assessments of depressive symptoms were conducted. Multi-level modeling indicated that high C-reactive protein (CRP) (but no other proinflammatory markers) predicted depressive symptom increases. Three-way interactions between different inflammatory biomarkers, sex, and months-to-follow-up predicted change in depressive symptoms. Higher interleukin-6 predicted increased depressive symptoms at 13-31 months after baseline assessment of depression and inflammation for females. Higher tumor necrosis factor-alpha predicted increased depressive symptoms at < 1 month after baseline for males and 13-31 months after baseline for females. Higher interleukin-8 in males predicted lower depressive symptoms at 31 months after baseline. Exploratory post-hoc analyses examined these predictive associations for specific subsets of depressive symptoms. These findings are the first to support the predictive association of elevated CRP for depressive symptoms in a community adolescent sample and serve as preliminary evidence that the relationship between cytokines and later depressive symptoms differs by sex, time-to-follow-up, and the specific biomarker.

SUBMITTER: Moriarity DP

PROVIDER: S-EPMC6655428 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Inflammatory Proteins Predict Change in Depressive Symptoms in Male and Female Adolescents.

Moriarity Daniel P DP Giollabhui Naoise Mac NM Ellman Lauren M LM Klugman Joshua J Coe Christopher L CL Abramson Lyn Y LY Alloy Lauren B LB

Clinical psychological science : a journal of the Association for Psychological Science 20190301 4

Inflammation has been implicated in depressive symptoms, but few studies use longitudinal designs with adolescents. Furthermore, the extant literature has yielded inconsistent results. Blood was collected from a community sample of 201 adolescents (109 female, ages 12.3-20.0) and analyzed for inflammatory proteins. Up to five follow-up assessments of depressive symptoms were conducted. Multi-level modeling indicated that high C-reactive protein (CRP) (but no other proinflammatory markers) predic ...[more]

PMID: 31341724

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Project description:Objectives: Reduced reward responsiveness, as measured by the event-related potential (ERP) component, the reward positivity (RewP), has been shown to play a role in the development of internalizing disorders, but implications for treatment remain unclear. In adult patients with anxiety and/or depression, reduced RewP has emerged as a predictor of greater change in symptoms following cognitive behavior therapy (CBT) or selective serotonin reuptake inhibitor (SSRI) treatment. The objectives of this preliminary study were to extend these findings to children and adolescents with anxiety disorders by evaluating RewP to reward as a predictor of change in anxiety severity or depressive symptoms following treatment with CBT or SSRI and to explore whether RewP differentially predicts response to one type of treatment. Methods: Patients (7-19 years old) with social and/or generalized anxiety disorder (N = 27) completed baseline measures of anxiety severity and depressive symptoms, as well as an ERP monetary reward anticipation and feedback task. RewP was measured in response to reward and breaking even feedback. Patients were then randomly assigned to CBT or SSRI treatment, and completed measures of anxiety and depressive symptom severity at the last treatment session. Results: Reduced reward responsiveness, as measured by RewP to rewards, predicted greater change in depressive symptoms following treatment, adjusting for baseline symptoms, age, and RewP to breaking even. RewP was not a significant predictor of change in anxiety symptoms. Although preliminary, exploratory analyses suggested that among anxious youth, RewP specifically predicted change in depressive symptoms following CBT, rather than SSRI. Conclusion: Results provide preliminary support for the utility of ERP measures of reward responsiveness in predicting treatment response in youth. With further research and standardization, ERP assessments could potentially be implemented in clinical settings to inform prognosis and treatment planning for youth with internalizing disorders.

Dataset Information

Inflammatory Proteins Predict Change in Depressive Symptoms in Male and Female Adolescents.

Publications

Inflammatory Proteins Predict Change in Depressive Symptoms in Male and Female Adolescents.

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