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FMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.


ABSTRACT: Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemplars from the same category, and two exemplars from different categories. We also administered two functional localizer tasks. A region of interest analysis was employed to evaluate a priori hypotheses about the lateral occipital complex (LOC) and early visual cortex (EVC). An exploratory whole brain analysis was also conducted. In the LOC and EVC, controls showed the expected reduced fMRI responses to repeated presentation of the same objects compared with different objects (i.e., fMRI adaptation for objects, p?

SUBMITTER: Lee J 

PROVIDER: S-EPMC6655550 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.

Lee Junghee J   Reavis Eric A EA   Engel Stephen A SA   Altshuler Lori L LL   Cohen Mark S MS   Glahn David C DC   Nuechterlein Keith H KH   Wynn Jonathan K JK   Green Michael F MF  

Human brain mapping 20181221 5


Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemp  ...[more]

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