Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era.

ABSTRACT: BACKGROUND:Enrichment of patients based on molecular biomarkers is increasingly used in early phase clinical trials. Molecular profiling of patients with advanced cancers can identify specific genomic alterations to inform decisions about investigational treatment(s). Our aim was to evaluate the outcomes of new patient referrals to a large academic solid tumor phase I clinical trial program after the implementation of molecular profiling. MATERIALS AND METHODS:Retrospective chart review of all new referrals to the Princess Margaret Cancer Centre (PM) phase I clinic from May 2012 to December 2014. Molecular profiling using either MALDI-TOF hotspot mutation genotyping or targeted panel DNA sequencing was performed for patients at PM or community hospitals through the institutional IMPACT/COM

SUBMITTER: Tan T 

PROVIDER: S-EPMC6656436 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature