Hydrodynamic radius coincides with the slip plane position in the electrokinetic behavior of lysozyme.

ABSTRACT: The zeta potential (ζ) is the effective charge energy of a solvated protein, describing the magnitude of electrostatic interactions in solution. It is commonly used in the assessment of adsorption processes and dispersion stability. Predicting ζ from molecular structure would be useful to the structure-based molecular design of drugs, proteins, and other molecules that hold charge-dependent function while remaining suspended in solution. One challenge in predicting ζ is identifying the location of the slip plane (X_SP ), a distance from the protein surface where ζ is theoretically defined. This study tests the hypothesis that the X_SP can be estimated by the Stokes-Einstein hydrodynamic radius (R_h ), using globular hen egg white lysozyme as a model system. Al

SUBMITTER: Grisham DR 

PROVIDER: S-EPMC6656557 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature