Unknown

Dataset Information

0

Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae.

ABSTRACT: The competence stimulating peptide (CSP) plays a key role in the regulation of pneumococcal quorum sensing (QS), a communication system that is critical to the infectivity of pneumococci. CSP functions through binding and activating a transmembrane receptor, ComD. Molecules that can modulate pneumococcal QS through intercepting CSP:ComD interaction may serve as new generation of antibacterial agents to treat pneumococcal infections. In this work, we systematically modified the N-terminus of CSP1, a region that is essential to ComD activation, to identify detailed structural features of the N-terminus that are responsible for its function. Our results revealed structural features that are optimal to achieve receptor activation and structure-activity trends that improve our understanding of CSP:ComD interaction, all of which will contribute to the design of novel pneumococcal QS modulators with higher potency and improved pharmacological properties.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6656601 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae.

Yang Yifang Y   Tal-Gan Yftah Y  

Bioorganic chemistry 20190518

The competence stimulating peptide (CSP) plays a key role in the regulation of pneumococcal quorum sensing (QS), a communication system that is critical to the infectivity of pneumococci. CSP functions through binding and activating a transmembrane receptor, ComD. Molecules that can modulate pneumococcal QS through intercepting CSP:ComD interaction may serve as new generation of antibacterial agents to treat pneumococcal infections. In this work, we systematically modified the N-terminus of CSP1  ...[more]

Similar Datasets

Unknown Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae.
| S-EPMC6071684 | biostudies-literature
Unknown Unveiling the Importance of Amide Protons in CSP:ComD Interactions in <i>Streptococcus pneumoniae</i>.
| S-EPMC6580532 | biostudies-literature
Unknown Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in <i>Streptococcus pneumoniae</i>.
| S-EPMC6983377 | biostudies-literature
Unknown Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation.
| S-EPMC5400695 | biostudies-literature
Unknown Attenuating the <i>Streptococcus pneumoniae</i> Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs.
| S-EPMC9106926 | biostudies-literature
Unknown Inhibition of competence development, horizontal gene transfer and virulence in Streptococcus pneumoniae by a modified competence stimulating peptide.
| S-EPMC3164649 | biostudies-literature
Unknown Structure-Activity Relationships of the Competence Stimulating Peptide in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor Activation.
| S-EPMC6138527 | biostudies-literature
Unknown Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements.
| S-EPMC1150823 | biostudies-other
Unknown Pharmacological Evaluation of Synthetic Dominant-Negative Peptides Derived from the Competence-Stimulating Peptide of <i>Streptococcus pneumoniae</i>.
| S-EPMC9112410 | biostudies-literature
Unknown Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae.
| S-EPMC6145841 | biostudies-literature