Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6656627 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.
Li Yuanyuan Y Xu Yanyong Y Jadhav Kavita K Zhu Yingdong Y Yin Liya L Zhang Yanqiao Y
Arteriosclerosis, thrombosis, and vascular biology 20190711 8
<h4>Objective</h4>To determine the role of hepatic FOXA3 (forkhead box A3) in lipid metabolism and atherosclerosis. Approach and Results: Hepatic FOXA3 expression was reduced in diabetic or high fat diet-fed mice or patients with nonalcoholic steatohepatitis. We then used adenoviruses to overexpress or knock down hepatic FOXA3 expression. Overexpression of FOXA3 in the liver increased hepatic ApoA-I (apolipoprotein A-I) expression, plasma HDL-C (high-density lipoprotein cholesterol) level, macro ...[more]
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