Ontology highlight
ABSTRACT:
SUBMITTER: Olbrich T
PROVIDER: S-EPMC6656781 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cell reports 20190701 3
The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have now performed a phenotypic chemical screen in human haploid HAP1 cells aiming to identify compounds that facilitate the maintenance of haploid cells. Our top hit was 10-Deacetyl-bac ...[more]