S-EPMC6657107 - Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes. - OmicsDI

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Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes.

ABSTRACT: Background:Visfatin is a multifaceted protein that plays an important role in regulating a variety of physiological and pathological processes, including obesity, diabetes and cardiovascular disease. However, circulating visfatin levels in atherosclerosis plaque progression in patients with type 2 diabetes, or its association with the vascular territory affected remain unclear. Methods:We evaluated the relationship between visfatin levels and carotid or femoral artery atherosclerosis in Chinese patients with type 2 diabetes. Serum levels of visfatin were measured by enzyme-linked immunosorbent assay (ELISA) in 97 inpatients with type 2 diabetes. Carotid and/or femoral atherosclerotic plaques were detected by B-mode ultrasound. Results:Serum visfatin levels were elevated in the group with atherosclerotic plaques compared to the control group without plaques [0.68 (0.46-1.58) versus 0.45 (0.23-0.76) ng/mL, respectively, P?=?0.0002]. Patients with carotid plaques showed higher visfatin levels than those with or without femoral plaques. Pearson's correlation analysis showed that serum visfatin levels were positively correlated with waist circumference (r?=?0.226, P?=?0.029), waist-hip ratio (r?=?0.221, P?=?0.032), TG (r?=?0.222, P?=?0.030) and number of plaques (r?=?0.275, P?=?0.009). Logistic regression analysis showed that a higher serum visfatin level was an independent predictor for the presence of atherosclerotic plaques. Conclusions:In conclusion, among patients with T2DM, serum visfatin levels were elevated in those with atherosclerotic plaques, especially in patients with carotid atherosclerotic plaques. Serum visfatin may serve as a predictor of atherosclerotic plaques in patients with T2DM.

SUBMITTER: Zheng LY

PROVIDER: S-EPMC6657107 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes.

Zheng Long-Yi LY Xu Xia X Wan Ren-Hui RH Xia Sheng S Lu Jin J Huang Qin Q

Diabetology & metabolic syndrome 20190724

<h4>Background</h4>Visfatin is a multifaceted protein that plays an important role in regulating a variety of physiological and pathological processes, including obesity, diabetes and cardiovascular disease. However, circulating visfatin levels in atherosclerosis plaque progression in patients with type 2 diabetes, or its association with the vascular territory affected remain unclear.<h4>Methods</h4>We evaluated the relationship between visfatin levels and carotid or femoral artery atherosclero ...[more]

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