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Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis.


ABSTRACT: BACKGROUND:Several studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive. We conducted this cumulative meta-analysis for a precise estimate of the relationship between IL-8 rs4073 polymorphism and acute pancreatitis. METHODS:We searched the electronic databases for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. For a better presentation of how the pooled ORs changed as updated evidence accumulated, we used forest plots from a cumulative meta-analysis method. RESULTS:Ten studies involving 1646 AP patients and 1816 controls were finally included in this meta-analysis. Cumulative meta-analyses indicated there is a consistent trend toward association after the initial discovery. Under the allelic, dominant, recessive and homozygous models, the pooled ORs were 1.265 (1.147-1.395, p?

SUBMITTER: Li Y 

PROVIDER: S-EPMC6657145 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis.

Li Yening Y   Bai Jing J   He Bing B   Wang Nan N   Wang Haoran H   Liu Dongliang D  

BMC medical genetics 20190724 1


<h4>Background</h4>Several studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive. We conducted this cumulative meta-analysis for a precise estimate of the relationship between IL-8 rs4073 polymorphism and acute pancreatitis.<h4>Methods</h4>We searched the electronic databases for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the s  ...[more]

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