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Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients.

ABSTRACT:

Impact statement

In this study, we report the development of a novel multimaterial segmented three-dimensional printing methodology to fabricate porous scaffolds containing discrete horizontal gradients of composition and porosity. This methodology is particularly beneficial to preparing porous scaffolds with intricate structures and graded compositions for the regeneration of complex tissues. The technique presented is compatible with many commercially available bioprinters commonly used in biofabrication, and can be adapted to better replicate the architectural and compositional requirements of individual tissues compared with traditional scaffold printing methods.

SUBMITTER: Diaz-Gomez L

PROVIDER: S-EPMC6657302 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients.

Diaz-Gomez Luis L Kontoyiannis Panayiotis D PD Melchiorri Anthony J AJ Mikos Antonios G AG

Tissue engineering. Part C, Methods 20190701 7

<h4>Impact statement</h4>In this study, we report the development of a novel multimaterial segmented three-dimensional printing methodology to fabricate porous scaffolds containing discrete horizontal gradients of composition and porosity. This methodology is particularly beneficial to preparing porous scaffolds with intricate structures and graded compositions for the regeneration of complex tissues. The technique presented is compatible with many commercially available bioprinters commonly use ...[more]

PMID: 31169080

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