Ontology highlight
ABSTRACT:
SUBMITTER: Sevdali E
PROVIDER: S-EPMC6657364 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sevdali Eirini E Katsantoni Eleni E Smulski Cristian R CR Moschovi Maria M Palassopoulou Maria M Kolokotsa Eleni-Nefeli EN Argentou Nikoletta N Giannakoulas Nikolaos N Adamaki Maria M Vassilopoulos Georgios G Polychronopoulou Sophia S Germenis Anastasios E AE Eibel Hermann H Speletas Matthaios M
Frontiers in oncology 20190718
BAFF, APRIL and their receptors regulate the survival, maturation and homeostasis of mature B-cells. Despite the lack of a functional role of BAFF/APRIL system during normal early B-cell development, previous studies indicated a contribution of these molecules in the pathogenesis of B-lineage acute lymphoblastic leukemia (B-ALL). Here, we evaluated the expression of this system in B-ALL and its involvement in spontaneous and drug-induced apoptosis of B-lymphoblasts, taking into consideration the ...[more]