Ontology highlight
ABSTRACT:
SUBMITTER: Wolf NM
PROVIDER: S-EPMC6657506 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wolf Nina M NM Lee Hyun H Choules Mary P MP Pauli Guido F GF Phansalkar Rasika R Anderson Jeffrey R JR Gao Wei W Ren Jinhong J Santarsiero Bernard D BD Lee Hanki H Cheng Jinhua J Jin Ying-Yu YY Ho Ngoc Anh NA Duc Nguyen Minh NM Suh Joo-Won JW Abad-Zapatero Celerino C Cho Sanghyun S
ACS infectious diseases 20190503 6
Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis ( M. tb) strains, ecumicin (ECU) and rufomycin I (RUFI) are being explored as promising new leads targeting cellular proteostasis via the caseinolytic protein ClpC1. Details of the binding topology and chemical mode of (inter)action of these cyclopeptides help drive further development of novel potency-optimized entities as tuberculosis drugs. ClpC1 M. tb protein constructs with mutations driving ...[more]