Ontology highlight
ABSTRACT:
SUBMITTER: Camerlingo R
PROVIDER: S-EPMC6657837 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Camerlingo Rosa R Miceli Roberta R Marra Laura L Rea Giuseppina G D'Agnano Igea I Nardella Marta M Montella Roberta R Morabito Alessandro A Normanno Nicola N Tirino Virginia V Rocco Gaetano G
PloS one 20190725 7
The epithelial-mesenchymal transition (EMT) plays a key role in tumor progression, drug resistance and metastasis. Recently, numerous microRNA (miRNA) have been described to regulate EMT in tumor progression. In this study, we found that conditioned medium from the LC212 non-small-cell lung cancer (NSCLC) cell line (LC212-CM) induces morphological changes and overexpression of Vimentin, CD90, SMAD 2/3, SLUG and TWIST in A549 NSCLC cells, consistent with a mesenchymal phenotype. To identify the s ...[more]