Ontology highlight
ABSTRACT:
SUBMITTER: Kitanaka N
PROVIDER: S-EPMC6658082 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kitanaka Nanako N Nakano Rei R Sugiura Kanae K Kitanaka Taku T Namba Shinichi S Konno Tadayoshi T Nakayama Tomohiro T Sugiya Hiroshi H
PloS one 20190725 7
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the immune response and inflammation. In this study, we investigated effect of the proinflammatory cytokine interleukin-1β (IL-1β) on IL-6 expression in canine dermal fibroblasts. IL-1β induced IL-6 mRNA expression and protein release in a time- and dose-dependent manner. When cells were treated with inhibitors of mitogen-activated protein kinases (MAPKs), the extracellular signal-regulated kinase (ERK) inhibitor FR1802 ...[more]