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National Cancer Institute Basket/Umbrella Clinical Trials: MATCH, LungMAP, and Beyond.


ABSTRACT: With advances in genetic testing and its common usage, the field of precision medicine has exploded in the field of oncology. The National Cancer Institute is uniquely positioned to lead in this area of research through its wide network of investigators, partnerships with pharmaceutical companies in drug development, and laboratory capabilities. It has developed a portfolio of trials as part of a Precision Medicine Initiative that uses various basket/umbrella designs to increase the understanding of treatment of cancer through genetic selection and targeted therapies. This article describes these trials, ALCHEMIST, LungMAP, NCI/NRG ALK Trial, MPACT, NCI-MATCH, and pediatric MATCH, and their contributions to the area of precision medicine.

SUBMITTER: Chen AP 

PROVIDER: S-EPMC6658131 | biostudies-literature | 2019 Jul/Aug

REPOSITORIES: biostudies-literature

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National Cancer Institute Basket/Umbrella Clinical Trials: MATCH, LungMAP, and Beyond.

Chen Alice P AP   Eljanne Mariam M   Harris Lyndsay L   Malik Shakuntala S   Seibel Nita L NL  

Cancer journal (Sudbury, Mass.) 20190701 4


With advances in genetic testing and its common usage, the field of precision medicine has exploded in the field of oncology. The National Cancer Institute is uniquely positioned to lead in this area of research through its wide network of investigators, partnerships with pharmaceutical companies in drug development, and laboratory capabilities. It has developed a portfolio of trials as part of a Precision Medicine Initiative that uses various basket/umbrella designs to increase the understandin  ...[more]

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