Dataset Information

Measurement reproducibility of slice-interleaved T1 and T2 mapping sequences over 20 months: A single center study.

ABSTRACT:

Background

Quantifying reproducibility of native T1 and T2 mapping over a long period (> 1 year) is necessary to assess whether changes in T1 and T2 over repeated sessions in a longitudinal study are associated with variability due to underlying tissue composition or technical confounders.

Objectives

To carry out a single-center phantom study to 1) investigate measurement reproducibility of slice-interleaved T1 (STONE) and T2 mapping over 20 months, 2) quantify sources of variability, and 3) compare reproducibility and measurements against reference spin-echo measurements.

Methods

MR imaging was performed on a 1.5 Tesla Philips Achieva scanner every 2-3 weeks over 20 months using the T1MES phantom. In each session, slice-interleaved T1 and T2 mapping was repeated 3 times for 5 slices, and maps were reconstructed using both 2-parameter and 3-parameter fit models. Reproducibility between sessions, and repeatability between repetitions and slices were evaluated using coefficients of variation (CV). Different sources of variability were quantified using variance decomposition analysis. The slice-interleaved measurement was compared to the spin-echo reference and MOLLI.

Results

Slice-interleaved T1 had excellent reproducibility and repeatability with a CV < 2%. The main sources of T1 variability were temperature in 2-parameter maps, and slice in 3-parameter maps. Superior between-session reproducibility to the spin-echo T1 was shown in 2-parameter maps, and similar reproducibility in 3-parameter maps. Superior reproducibility to MOLLI T1 was also shown. Similar measurements to the spin-echo T1 were observed with linear regression slopes of 0.94-0.99, but slight underestimation. Slice-interleaved T2 showed good reproducibility and repeatability with a CV < 7%. The main source of T2 variability was slice location/orientation. Between-session reproducibility was lower than the spin-echo T2 reference and showed good measurement agreement with linear regression slopes of 0.78-1.06.

Conclusions

Slice-interleaved T1 and T2 mapping sequences yield excellent long-term reproducibility over 20 months.

SUBMITTER: Jang J

PROVIDER: S-EPMC6658153 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Measurement reproducibility of slice-interleaved T1 and T2 mapping sequences over 20 months: A single center study.

Jang Jihye J Ngo Long H LH Captur Gabriella G Moon James C JC Nezafat Reza R

PloS one 20190725 7

<h4>Background</h4>Quantifying reproducibility of native T1 and T2 mapping over a long period (> 1 year) is necessary to assess whether changes in T1 and T2 over repeated sessions in a longitudinal study are associated with variability due to underlying tissue composition or technical confounders.<h4>Objectives</h4>To carry out a single-center phantom study to 1) investigate measurement reproducibility of slice-interleaved T1 (STONE) and T2 mapping over 20 months, 2) quantify sources of variabil ...[more]

PMID: 31344078

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Project description:PurposeTo develop and evaluate a free-breathing slice-interleaved T2 mapping sequence by proposing a new slice-selective T2 magnetization preparation (T2 prep) sequence that allows interleaved data acquisition for different slices in subsequent heartbeats.MethodsWe developed a slice-selective T2 prep for myocardial T2 mapping by adding slice-selective gradients to a conventional single-slice T2 prep sequence. In this sequence, five slices are acquired during five consecutive heartbeats, each using a slice-selective T2 prep. The scheme was repeated four times using different T2 prep echo times. We compared the performance of the proposed slice-interleaved T2 mapping sequence and the conventional single-slice T2 mapping sequence in term of accuracy, precision, and reproducibility using phantom experiments and in vivo imaging in 10 healthy subjects. We also evaluated the feasibility of the proposed sequence in 28 patients with cardiovascular disease, and the quality of the maps was scored subjectively. Furthermore, we investigated the impact of through-plane motion by comparing T2 measurements acquired during end-systole versus mid-diastole.ResultsT2 measurements using a slice-interleaved T2 mapping sequence were correlated with a spin echo (r(2) = 0.88) and single-slice T2 mapping sequence (r(2) = 0.98). The mean myocardial T2 values were correlated between slice-interleaved (48 ms) and single-slice (51 ms) T2 mapping sequences. Subjective scores of T2 map quality were good to excellent in 81% of the maps in patients. There was no difference in T2 measurements between end-systole versus mid-diastole.ConclusionsThe proposed free-breathing slice-interleaved T2 mapping sequence allows T2 measurements of five left ventricular slices in 20 heartbeats with similar reproducibility and precision as the single-slice T2 mapping sequence but with a four-fold reduction in acquisition time. Magn Reson Med 76:555-565, 2016. © 2015 Wiley Periodicals, Inc.

Dataset Information

Measurement reproducibility of slice-interleaved T1 and T2 mapping sequences over 20 months: A single center study.

Background

Objectives

Methods

Results

Conclusions

Publications

Measurement reproducibility of slice-interleaved T1 and T2 mapping sequences over 20 months: A single center study.

Similar Datasets

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