Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences.

ABSTRACT: Anti-drug vaccines have potential as new interventions against substance use disorder (SUD). However, given the challenges seen with inter-individual variability in SUD vaccine trials to date, new interventions should ensure a robust immune response and safety profile among a diverse population. This requires accounting for sex and heritable genetic differences in response to both abused substances as well as the vaccination itself. To test response variability to our heroin-tetanus toxoid (Her-TT) immunoconjugate vaccine, we vaccinated male and female mice from several mouse strains including Swiss Webster (SW), BALB/c, and Jackson diversity mice (J:DO). Previous studies with vaccinated male SW mice demonstrated a rare hypersensitivity resulting in mice rapidly expiring with exposure to a

SUBMITTER: Hwang CS 

PROVIDER: S-EPMC6658211 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature