Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura Y
PROVIDER: S-EPMC6658523 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20190725 1
Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate immune responses may have negative effects on transplanted iPSC-CMs. Here, we demonstrated that natural killer cells (NKCs) infiltrated in iPSC-CM transplants even in a syngeneic m ...[more]