Ontology highlight
ABSTRACT:
SUBMITTER: Oppermann J
PROVIDER: S-EPMC6658528 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Oppermann Johannes J Fischer Paul P Silapetere Arita A Liepe Bernhard B Rodriguez-Rozada Silvia S Flores-Uribe José J Schiewer Enrico E Keidel Anke A Vierock Johannes J Kaufmann Joel J Broser Matthias M Luck Meike M Bartl Franz F Hildebrandt Peter P Wiegert J Simon JS Béjà Oded O Hegemann Peter P Wietek Jonas J
Nature communications 20190725 1
Channelrhodopsins (ChRs) are algal light-gated ion channels widely used as optogenetic tools for manipulating neuronal activity. ChRs desensitize under continuous bright-light illumination, resulting in a significant decline of photocurrents. Here we describe a metagenomically identified family of phylogenetically distinct anion-conducting ChRs (designated MerMAIDs). MerMAIDs almost completely desensitize during continuous illumination due to accumulation of a late non-conducting photointermedia ...[more]