Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC6659023 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chen Chunhai C Zhong Xiaoling X Smith Derek K DK Tai Wenjiao W Yang Jianjing J Zou Yuhua Y Wang Lei-Lei LL Sun Jiahong J Qin Song S Zhang Chun-Li CL
Cerebral cortex (New York, N.Y. : 1991) 20190101 1
Injury to the adult brain induces activation of local astrocytes, which serves as a compensatory response that modulates tissue damage and recovery. However, the mechanism governing astrocyte activation during brain injury remains largely unknown. Here we provide in vivo evidence that SOX2, a transcription factor critical for stem cells and brain development, is also required for injury-induced activation of adult cortical astrocytes. Genome-wide chromatin immunoprecipitation-seq analysis of mou ...[more]