Dataset Information

Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey.

ABSTRACT:

Background

Large-scale studies comparing glomerular disease frequencies across continents are lacking.

Methods

We surveyed 29 nephropathology laboratories in four continents using a standardized data collection form. We obtained recent consecutive kidney biopsy diagnosis frequencies at each center and summary demographics for each diagnosis. This report focuses on glomerular disease frequencies by region and race/ethnicity.

Results

Among 42?603 glomerular disease diagnoses reported (median age 47?years, 52% male, 57% white), from a total of 60?340 diagnoses, glomerular disease subtype frequencies differed considerably by continent. Diabetic glomerulosclerosis (GS; 19.1%) and focal segmental glomerulosclerosis (FSGS; 19.1%) predominated in North America; lupus nephritis (38.1%) and FSGS (15.8%) predominated in Latin America; IgA nephropathy (IgAN; 22.1%) and FSGS (14.9%) predominated in Europe; and IgAN (39.5%) and lupus nephritis (16.8%) predominated in Asia. After stratifying by race, diabetic GS (17.4% versus 4.3%, P?ConclusionsWe determined that glomerular disease frequencies differed by continent, even among patients of similar race/ethnicity. Regional environmental and lifestyle factors, and local biopsy policies, might influence glomerular disease epidemiology independently of race/ethnicity.

SUBMITTER: O'Shaughnessy MM

PROVIDER: S-EPMC6659026 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Publications

Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey.

O'Shaughnessy Michelle M MM Hogan Susan L SL Thompson Bawana D BD Coppo Rosanna R Fogo Agnes B AB Jennette J Charles JC

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20180401 4

<h4>Background</h4>Large-scale studies comparing glomerular disease frequencies across continents are lacking.<h4>Methods</h4>We surveyed 29 nephropathology laboratories in four continents using a standardized data collection form. We obtained recent consecutive kidney biopsy diagnosis frequencies at each center and summary demographics for each diagnosis. This report focuses on glomerular disease frequencies by region and race/ethnicity.<h4>Results</h4>Among 42 603 glomerular disease diagnoses ...[more]

PMID: 29106637

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Project description:Background and objectivesHigh-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric glomerular diseases in China.Design, setting, participants, & measurementsWe previously conducted a nationwide kidney biopsy survey including 71,151 patients over an 11-year period from January 2004 to December 2014. A total of 7962 children younger than 18 years old from 115 hospitals across China with biopsy-proven glomerular diseases were included in this study. The demographic and clinical variables were extracted from referral records and pathology reports. The composition of pediatric glomerular diseases and clinicopathologic correlations in different sexes, age groups, and regions were assessed. The changing patterns of common glomerulopathies over the study period were examined.ResultsNephrotic syndrome (50%) was the most frequent indication for kidney biopsy in children. Minimal change disease was the most common primary glomerular disease (29%) followed by IgA nephropathy (17%). Henoch-Schonlein purpura nephritis (13%) and lupus nephritis (9%) were the most common secondary glomerular diseases. The proportion of minimal change disease was significant higher in boys (38%) than in girls (13%), whereas lupus nephritis was more prevalent in girls (20%) than in boys (3%). Purpura nephritis (23%) was the major pathologic pattern in younger children (0-12 years old), whereas minimal change disease (33%) was the most common glomerulopathy in adolescents (13-18 years old). The clinicopathologic correlations were slightly different between sexes and age groups. We observed increases in the proportions of minimal change disease, purpura nephritis, and membranous nephropathy over the study period that were contemporaneous with a fall in the proportion of FSGS.ConclusionsThe spectrum of glomerular diseases among children varied across sexes, age groups, and regions and changed substantially from 2004 to 2014 in China.

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Dataset Information

Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey.

Background

Methods

Results

Publications

Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey.

Similar Datasets

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