Long non-coding RNA MIAT promotes papillary thyroid cancer progression through upregulating LASP1.

ABSTRACT:

Background

Accumulating evidences indicate that long non-coding RNAs (lncRNAs) play an important role in initiation and development of thyroid cancer. However, the underlying molecular mechanism remains elusive.

Methods

To explore potential oncogenic and tumor suppressive lncRNAs in papillary thyroid cancer (PTC), we performed RNA sequencing to discover differentially expression lncRNAs between PTC tissues and matched normal tissues. RT-qPCR was used to validate differentially expressed lncRNAs. Bioinformatic analysis was performed to predicted potential miRNA and gene which might be regulated by MIAT. Cell proliferation, invasion and cycle assay were conducted to study the function of MIAT and LASP1 in PTC.

Results

Through analysis of RNA sequencing, we observed that

SUBMITTER: Liu W 

PROVIDER: S-EPMC6659215 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature