Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial.
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ABSTRACT:
SUBMITTER: Saadati S
PROVIDER: S-EPMC6659284 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial.
Saadati Saeede S Sadeghi Amir A Mansour Asieh A Yari Zahra Z Poustchi Hossein H Hedayati Mehdi M Hatami Behzad B Hekmatdoost Azita A
BMC gastroenterology 20190725 1
<h4>Background</h4>The aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD).<h4>Methods</h4>Fifty patients with NAFLD were randomized to receive lifestyle modification advice plus either 1500 mg curcumin or the same amount of placebo for 12 weeks.<h4>Results</h4>Curcumin supplementation was associated with significant decrease in hepatic fibrosis (p < 0.001), and n ...[more]
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Project description:Resveratrol treatment has shown beneficial effects on experimental models of non-alcoholic liver disease (NAFLD). In this pilot-size, clinical trial we teated the therapeutic potential in NAFLD patients. We found only limited clinical effect of resveratrol treatment.
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Project description:Background: Non-alcoholic fatty liver disease (NAFLD) can be ameliorated by weight loss although difficult to maintain. Emerging evidence indicates that prebiotics and antibiotics improve NAFLD. Aim: To determine whether inulin supplementation after brief metronidazole therapy is effective in reducing alanine aminotransferase (ALT) and maintaining weight loss achieved through a very-low-calorie diet (VLCD) among people with NAFLD. Methods: Sixty-two people with NAFLD commenced 4-week VLCD using Optifast meal replacements (600 kcal/day). Sixty were then randomised into a 12-week double-blind, placebo-controlled, parallel three-arm trial: (1) 400 mg metronidazole twice daily in Week 1 then inulin 4 g twice daily OR (2) placebo twice daily in week one then inulin OR (3) placebo-placebo. Main outcomes were ALT and body weight at 12 weeks. Fecal microbiota changes were also evaluated. Results: Mean body mass index (BMI) and ALT reduced after VLCD by 2.4 kg/m2 and 11 U/L, respectively. ALT further decreased after metronidazole-inulin compared to after placebo-placebo (mean ALT change -19.6 vs. -0.2 U/L, respectively; p = 0.026); however, weight loss maintenance did not differ. VLCD treatment decreased the ratio of Firmicutes/Bacteroidetes (p = 0.002). Conclusion: Brief metronidazole followed by inulin supplementation can reduce ALT beyond that achieved after VLCD in patients with NAFLD.
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