Dataset Information

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity.

ABSTRACT: In working memory (WM), the ability to concurrently integrate different types of information and to maintain or manipulate them promotes the flow of ongoing tasks. WM is a key component of normal human cognition. In this study, we applied a combined voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis to investigate the relationship between the ability of object and spatial working memory (WM), and regional gray matter density (GMD), as well as intrinsic functional connectivity. The VBM analysis showed a positive correlation between the individual difference of object WM and GMD in the right middle occipital gyrus (MOG) and the left superior temporal gyrus (STG), which are responsible for coding object information and processing the shape of an object. The individual difference of the spatial WM was positively related to GMD in the right middle frontal gyrus (MFG) located in the dorsolateral prefrontal cortex (dlPFC), which confirmed that it is an important region for memory stores and maintains WM spatial representations. Further functional connectivity analysis revealed that the individual difference of object WM was significantly correlated with the rsFC of right intraparietal sulcus (IPS) - left postcentral gyrus (PostCG)/right precentral gyrus (PreCG)/left Supplementary Motor Area (SMA). While the capacity of spatial WM was significantly associated with the FC strength of the left dlPFC - left precuneus, right dlPFC - right MFG, and the left superior frontal sulcus (SFS) - left SMA/ right inferior parietal lobe (IPL). Our findings suggest that object WM is associated with the structure and functional organization of the brain regions involved in the ventral pathway (occipital - temporal regions) and the capacity of spatial WM is related to the dorsal pathway (frontal - parietal regions).

SUBMITTER: Ren Z

PROVIDER: S-EPMC6659551 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity.

Ren Zhiting Z Zhang Yao Y He Hong H Feng Qiuyang Q Bi Taiyong T Qiu Jiang J

Frontiers in human neuroscience 20190719

In working memory (WM), the ability to concurrently integrate different types of information and to maintain or manipulate them promotes the flow of ongoing tasks. WM is a key component of normal human cognition. In this study, we applied a combined voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis to investigate the relationship between the ability of object and spatial working memory (WM), and regional gray matter density (GMD), as well as intrinsic functi ...[more]

PMID: 31379543

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Project description:Transcranial direct and alternating current stimulation (tDCS and tACS, respectively) entail capability to modulate human brain dynamics and cognition. However, the comparability of these approaches at the level of large-scale functional networks has not been thoroughly investigated. In this study, 44 subjects were randomly assigned to receive sham (N = 15), tDCS (N = 15), or tACS (N = 14). The first electrode (anode in tDCS) was positioned over the left dorsolateral prefrontal cortex, the target area, and the second electrode (cathode in tDCS) was placed over the right supraorbital region. tDCS was delivered with a constant current of 2 mA. tACS was fixed to 2 mA peak-to-peak with 6 Hz frequency. Stimulation was applied concurrently with functional magnetic resonance imaging (fMRI) acquisitions, both at rest and during the performance of a verbal working memory (WM) task. After stimulation, subjects repeated the fMRI WM task. Our results indicated that at rest, tDCS increased functional connectivity particularly within the default-mode network (DMN), while tACS decreased it. When comparing both fMRI WM tasks, it was observed that tDCS displayed decreased brain activity post-stimulation as compared to online. Conversely, tACS effects were driven by neural increases online as compared to post-stimulation. Interestingly, both effects primarily occurred within DMN-related areas. Regarding the differences in each fMRI WM task, during the online fMRI WM task, tACS engaged distributed neural resources which did not overlap with the WM-dependent activity pattern, but with some posterior DMN regions. In contrast, during the post-stimulation fMRI WM task, tDCS strengthened prefrontal DMN deactivations, being these activity reductions associated with faster responses. Furthermore, it was observed that tDCS neural responses presented certain consistency across distinct fMRI modalities, while tACS did not. In sum, tDCS and tACS modulate fMRI-derived network dynamics differently. However, both effects seem to focus on DMN regions and the WM network-DMN shift, which are highly affected in aging and disease. Thus, albeit exploratory and needing further replication with larger samples, our results might provide a refined understanding of how the DMN functioning can be externally modulated through commonly used non-invasive brain stimulation techniques, which may be of eventual clinical relevance.

Dataset Information

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity.

Publications

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity.

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