Ontology highlight
ABSTRACT:
SUBMITTER: Warmack RA
PROVIDER: S-EPMC6659688 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190726 1
Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20-34 fibril with and without the disease-associated PTM, L-isoaspartate, at position 23 (L-isoAsp23). Both wild-type and L-isoAsp23 protofilaments adopt β-helix-like folds with tightly packed cores, resembling the cores of full-length fibrillar Aβ structures, and both self-associate through two distinct inte ...[more]