Ontology highlight
ABSTRACT:
SUBMITTER: Li ZH
PROVIDER: S-EPMC6660039 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Li Zhi-Hui ZH Wang Yi-Fei YF He Dan-Dan DD Zhang Xue-Mei XM Zhou Ying-Lian YL Yue Hui H Huang Shan S Fu Zheng Z Zhang Ling-Yu LY Mao Zhu-Qing ZQ Li Shuang S Zhang Chen-Yu CY Chen Xi X Fu Jin J
Aging 20190701 13
T helper 17 (Th17) cells are regarded as key factors in the pathogenesis of multiple sclerosis (MS). Although the involvement of certain microRNAs (miRNAs) in the development of MS has been reported, their roles in Th17 cell differentiation and MS pathogenesis remain elusive. In this study, we identified that let-7f-5p expression is significantly downregulated in CD4<sup>+</sup> T cells from MS patients and during the process of Th17 differentiation. The overexpression of let-7f-5p suppressed Th ...[more]