Age-related changes in B cell metabolism.
Ontology highlight
ABSTRACT:
SUBMITTER: Kurupati RK
PROVIDER: S-EPMC6660053 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Age-related changes in B cell metabolism.
Kurupati Raj K RK Haut Larissa H LH Schmader Kenneth E KE Ertl Hildegund Cj HC
Aging 20190701 13
Antibody responses to vaccinations or infections decline upon aging. In this study we tested if metabolic changes in B cells may contribute to attenuation of responses to influenza vaccination in aged humans. Our data show that aging affects mitochondrial functions in B cells leading to increases in mitochondrial reactive oxygen species (MROS) and mitochondrial mass (MM) in some aged B cell subsets and decreases in expression levels of Sirtuin 1 (SIRT1), Forkhead box protein (FOX)O1 and carnitin ...[more]
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This model is described in the article:
Oxidative changes and
signalling pathways are pivotal in initiating age-related
changes in articular cartilage
Wang Hui1, David A Young1, Andrew D
Rowan1, Xin Xu2, Tim E Cawston1, Carole J Proctor1,3
Annals of the Rheumatic Diseases
Abstract:
Objective: To use a computational approach to investigate
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2024-09-02 | BIOMD0000000560 | BioModels
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