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Parietal neurons encode information sampling based on decision uncertainty.

ABSTRACT: During natural behavior, animals actively gather information that is relevant for learning or actions; however, the mechanisms of active sampling are rarely investigated. We tested parietal neurons involved in oculomotor control in a task in which monkeys made saccades to gather visual information relevant to a subsequent action. We show that the neurons encode, before the saccade, the information gain (reduction in decision uncertainty) that the saccade was expected to bring for the following action. Sensitivity to information gain correlates with the monkeys' efficiency at processing the information in the post-saccadic fixation, but is independent of neuronal reward sensitivity. Reward sensitivity, in turn, is unreliable across task contexts, inconsistent with the view that the cells encode economic utility. The findings suggest that parietal cells involved in oculomotor decisions show uncertainty-dependent boosts of neural gain that facilitate the implementation of active sampling policies, including the selection of relevant cues and the efficient use of the information delivered by these cues.

SUBMITTER: Horan M

PROVIDER: S-EPMC6660422 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Parietal neurons encode information sampling based on decision uncertainty.

Horan Mattias M Daddaoua Nabil N Gottlieb Jacqueline J

Nature neuroscience 20190708 8

During natural behavior, animals actively gather information that is relevant for learning or actions; however, the mechanisms of active sampling are rarely investigated. We tested parietal neurons involved in oculomotor control in a task in which monkeys made saccades to gather visual information relevant to a subsequent action. We show that the neurons encode, before the saccade, the information gain (reduction in decision uncertainty) that the saccade was expected to bring for the following a ...[more]

PMID: 31285613

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Project description:The paraventricular nucleus of the thalamus (PVT) has been implicated in cue-induced motivated behaviors. Although reward-associated cues (conditioned stimuli, CSs) contain different types of information including predictive information of future reward delivery and incentive (motivational) value of the reward, it remains unknown whether PVT neurons represent predictive and incentive information of CSs. It is suggested that neural activity just after the onset of CSs (early activity) and that just before reward delivery (late activity) might more strongly represent predictive and incentive information, respectively. In this study, rats were trained to lick a tube, which was protruded close to their mouth just after a CS, to obtain a reward (sucrose or water) (cue-induced licking task). Auditory and visual CSs were used: each elemental cue (CS) predicted reward or non-reward outcome, while simultaneous presentation of the two elemental cues (configural cues) predicted the opposite reward outcome. We recorded PVT neurons in the cue-induced licking task, and report that half of the CS-responsive PVT neurons responded selectively to the CSs predicting reward outcome regardless of physical property of the cues (CS+-selective). In addition, the early activity of the CS+-selective neurons discriminated reward/non-reward association (predictive information) and was less sensitive to reward value and motivation reflected by lick latency (incentive information), while the late activity of the CS+-selective neurons was correlated with reward value and motivation rather than reward/non-reward association. Early and late population activity of the CS+-selective neurons also represented predictive and incentive information of the CSs, respectively. On the other hand, activity of more than half of the PVT neurons was correlated with individual licking during licking to acquire reward. Taken together, the results suggest that the PVT neurons engage in different neural processes involved in cue-induced motivated behaviors: CS encoding to determine reward availability and form motivation for reward-seeking behavior, and hedonic mouth movements during reward consumption.

Dataset Information

Parietal neurons encode information sampling based on decision uncertainty.

Publications

Parietal neurons encode information sampling based on decision uncertainty.

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