Ontology highlight
ABSTRACT:
SUBMITTER: Mao Q
PROVIDER: S-EPMC6660426 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Mao Qingxiang Q Wu Shaogen S Gu Xiyao X Du Shibin S Mo Kai K Sun Linlin L Cao Jing J Bekker Alex A Chen Liyong L Tao Yuan-Xiang YX
International journal of cancer 20190205 8
Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy-induced neuropathic pain. K<sub>2p</sub> 1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection of the chemotherapy agent paclitaxel time-dependently downregulates the expression of K <sub>2p</sub> 1.1 mRNA and its coding K<sub>2p</sub> 1.1 protein in the DRG neurons. Rescuing this downregulation mi ...[more]