RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas.
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ABSTRACT:
SUBMITTER: Wirthschaft P
PROVIDER: S-EPMC6660512 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas.
Wirthschaft Peter P Bode Julia J Soni Himanshu H Dietrich Fabio F Krüwel Thomas T Fischer Bernd B Knobbe-Thomsen Christiane B CB Rossetti Giulia G Hentschel Andreas A Mack Norman N Schönig Kai K Breckwoldt Michael O MO Schmandke André A Pusch Stefan S Medenbach Jan J Bendszus Martin M Schwab Martin E ME von Deimling Andreas A Kool Marcel M Herold-Mende Christel C Reifenberger Guido G Ahrends Robert R Tews Björn B
Acta neuropathologica 20190506 2
Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein Nogo-A prevents cell migration by activating inhibitory RhoA signaling. The mechanisms behind this long-known phenomenon remained elusive so far, precluding a targeted therapeutic intervention. This study demonstrates that the prevalent activation of AKT in gliomas increases the ER protein-folding capacity and enables tumor cells to utilize a side effec ...[more]
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