Screening dataset of food components that enhance transcriptional activity of PGC1-beta.
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ABSTRACT:
SUBMITTER: Nakai S
PROVIDER: S-EPMC6660609 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Screening dataset of food components that enhance transcriptional activity of PGC1-beta.
Nakai Shiho S Uchitomi Ran R Matsuda Rintaro R Onishi Takumi T Hatazawa Yukino Y Kamei Yasutomi Y
Data in brief 20190306
PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β. We found that soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β, see "Genistein, daidzein, and resveratrols stimulate ...[more]
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