Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC6660777 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Yang Zhuo Z Wan Yue Y Tao Pingdong P Qiang Min M Dong Xue X Lin Chih-Wei CW Yang Guang G Zheng Tianqing T Lerner Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20190708 30
Generating and improving antibodies and peptides that bind specifically to membrane protein targets such as ion channels and G protein-coupled receptors (GPCRs) can be challenging using established selection methods. Current strategies are often limited by difficulties in the presentation of the antigen or the efficiency of the selection process. Here, we report a method for obtaining antibodies specific for whole cell membrane-associated antigens which combines a cell-cell interaction format ba ...[more]