Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
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ABSTRACT:
SUBMITTER: Khera AV
PROVIDER: S-EPMC6661115 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
Khera Amit V AV Chaffin Mark M Wade Kaitlin H KH Zahid Sohail S Brancale Joseph J Xia Rui R Distefano Marina M Senol-Cosar Ozlem O Haas Mary E ME Bick Alexander A Aragam Krishna G KG Lander Eric S ES Smith George Davey GD Mason-Suares Heather H Fornage Myriam M Lebo Matthew M Timpson Nicholas J NJ Kaplan Lee M LM Kathiresan Sekar S
Cell 20190401 3
Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants. Here we derive and validate a new polygenic predictor comprised of 2.1 million common variants to quantify this susceptibility and test this predictor in more than 300,000 individuals ranging from m ...[more]
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