Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder.

ABSTRACT:

Objective

Inflammation has been implicated in the aetiology of mental illness. We conducted the first systematic review and meta-analysis of the association between peripheral markers of inflammation and generalised anxiety disorder (GAD).

Design

Systematic review and meta-analysis of studies measuring peripheral cytokine levels in people with GAD compared with controls.

Data sources

MEDLINE (1950-), EMBASE (1947-), PsycINFO (1872-) and Web of Science (1945-) databases up until January 2018.

Eligibility criteria

Primary, quantitative research studies of people with a diagnosis of GAD assessed using a standardised clinical interview that measured peripheral inflammatory markers.

Data extraction and synthesis

Two independent reviewers extracted data and as

SUBMITTER: Costello H 

PROVIDER: S-EPMC6661660 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature