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Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa.


ABSTRACT: Two alkaloids, belonging to benzylisoquinoline alkaloids, were isolated from Annona squamosa. One of these alkaloids, 6, 7-dimethoxy-1-(?-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline, was isolated for the first time from natural sources, while, the alkaloid, Coclaurine was known in Annona squamosa L. Moreover, the isolated alkaloids tested for the anti-cancer activities on various cell lines (HepG-2, MCF-7, and HCT-116).

SUBMITTER: Al-Ghazzawi AM 

PROVIDER: S-EPMC6661725 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant <i>Annona squamosa</i>.

Al-Ghazzawi Adel M AM  

BMC chemistry 20190204 1


Two alkaloids, belonging to benzylisoquinoline alkaloids, were isolated from <i>Annona squamosa</i>. One of these alkaloids, 6, 7-dimethoxy-1-(α-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline, was isolated for the first time from natural sources, while, the alkaloid, Coclaurine was known in <i>Annona squamosa</i> L. Moreover, the isolated alkaloids tested for the anti-cancer activities on various cell lines (HepG-2, MCF-7, and HCT-116). ...[more]

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