Ontology highlight
ABSTRACT:
SUBMITTER: Kang Y
PROVIDER: S-EPMC6662421 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kang Yao Y Sun Wen W Li Shuyi S Li Mingle M Fan Jiangli J Du Jianjun J Liang Xing-Jie XJ Peng Xiaojun X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190430 13
Targeted drug delivery systems (TDDSs) provide a promising approach to overcome the side effect of traditional chemotherapy by specific tumor targeting and drug release. Hyaluronan (HA), as a selective CD44 targeting group, has been widely used in TDDSs for chemotherapy. However, different molecular weight HAs would demonstrate different binding ability to CD44, which may result in different therapeutic effects. Herein, a silica/hydroxyapatite (MSNs/HAP) hybrid carrier loaded with anticancer dru ...[more]