Ontology highlight
ABSTRACT:
SUBMITTER: McFeely SJ
PROVIDER: S-EPMC6662428 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
McFeely Savannah J SJ Ritchie Tasha K TK Yu Jingjing J Nordmark Anna A Levy René H RH Ragueneau-Majlessi Isabelle I
Clinical and translational science 20190312 4
Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 facilitate the uptake of drugs and endogenous compounds into the liver. In recent years, the impact of these transporters on drug-drug interactions (DDIs) has become a focus of research, and the evaluation of their role in drug disposition is recommended by regulatory agencies worldwide.<sup>1-3</sup> Although sensitive substrates of OATP1B1/1B3 have been identified in the literature and probe drugs have been proposed by regulatory agen ...[more]