Corrigendum to "Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells".
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ABSTRACT:
SUBMITTER: Kwon EB
PROVIDER: S-EPMC6662453 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Corrigendum to "<i>Zanthoxylum ailanthoides</i> Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells".
Kwon Eun-Bin EB Kang Myung-Ji MJ Kim Soo-Yeon SY Lee Yong-Moon YM Lee Mi-Kyeong MK Yuk Heung Joo HJ Ryu Hyung Won HW Lee Su Ui SU Oh Sei-Ryang SR Moon Dong-Oh DO Lee Hyun-Sun HS Kim Mun-Ock MO
Evidence-based complementary and alternative medicine : eCAM 20190714
[This corrects the article DOI: 10.1155/2018/3140267.]. ...[more]
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2023-12-05 | GSE248903 | GEO
Project description:Lipid metabolism is important for health and insulin action, yet the fundamental process of regulating lipid metabolism during muscle contraction is incompletely understood. Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO) mice display decreased fatty acid (FA) oxidation during treadmill exercise. LKB1 MKO mice also show decreased muscle SIK3 activity, increased histone deacetylase 4 expression, decreased NAD? concentration and SIRT1 activity, and decreased expression of genes involved in FA oxidation. In AMP-activated protein kinase (AMPK)?2 KO mice, substrate use was similar to that in WT mice, which excluded that decreased FA oxidation in LKB1 MKO mice was due to decreased AMPK?2 activity. Additionally, LKB1 MKO muscle demonstrated decreased FA oxidation in vitro. A markedly decreased phosphorylation of TBC1D1, a proposed regulator of FA transport, and a low CoA content could contribute to the low FA oxidation in LKB1 MKO. LKB1 deficiency did not reduce muscle glucose uptake or oxidation during exercise in vivo, excluding a general impairment of substrate use during exercise in LKB1 MKO mice. Our findings demonstrate that LKB1 is a novel molecular regulator of major importance for FA oxidation but not glucose uptake in muscle during exercise.
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