Ontology highlight
ABSTRACT:
SUBMITTER: Fu Q
PROVIDER: S-EPMC6662550 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Fu Qiang Q Chen Mingqing M Anderson Jason T JT Sun Xinxin X Hu Shuiying S Sparreboom Alex A Baker Sharyn D SD
Clinical and translational science 20190406 4
Regorafenib, a multikinase inhibitor used in the treatment of various solid tumors, undergoes extensive uridine 5'-diphosphate glucuronosyltransferase (Ugt)1a9-mediated glucuronidation to form regorafenib-N-β-glucuronide (M7; RG), but the contribution of hepatic uptake transporters, such as organic anion-transporting polypeptide (Oatp)1b2, to the pharmacokinetics of regorafenib remains poorly understood. Using NONMEM-based, population-based, parent-metabolite modeling, we found that Oatp1b2 and ...[more]