Ontology highlight
ABSTRACT:
SUBMITTER: Marques C
PROVIDER: S-EPMC6662558 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Marques Cindy C Carvelli Julien J Biard Lucie L Faguer Stanislas S Provôt François F Matignon Marie M Boffa Jean-Jacques JJ Plaisier Emmanuelle E Hertig Alexandre A Touzot Maxime M Moranne Olivier O Belenfant Xavier X Annane Djillali D Quéméneur Thomas T Cadranel Jacques J Izzedine Hassan H Bréchot Nicolas N Cacoub Patrice P Piedrafita Alexis A Jourde-Chiche Noémie N Saadoun David D
Frontiers in immunology 20190718
We report the overall and renal outcome in a French nationwide multicenter cohort of 119 patients with anti-glomerular basement membrane (anti-GBM) disease. Sixty-four patients (54%) had an exclusive renal involvement, 7 (6%) an isolated alveolar hemorrhage and 48 (40%) a combined renal and pulmonary involvement. Initial renal replacement therapy (RRT) was required in 78% of patients; 82% received plasmapheresis, 82% cyclophosphamide, and 9% rituximab. ANCA positive (28%) patients were older (70 ...[more]