HOXA9 methylation and blood vessel invasion in FFPE tissues for prognostic stratification of stage I lung adenocarcinoma patients.
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ABSTRACT:
SUBMITTER: Lissa D
PROVIDER: S-EPMC6662588 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
HOXA9 methylation and blood vessel invasion in FFPE tissues for prognostic stratification of stage I lung adenocarcinoma patients.
Lissa Delphine D Ishigame Teruhide T Noro Rintaro R Tucker Marguerite J MJ Bliskovsky Valery V Shema Steven S Beck Jessica A JA Bowman Elise D ED Harris Curtis C CC Robles Ana I AI
Lung cancer (Amsterdam, Netherlands) 20180522
<h4>Objectives</h4>Surgery with curative intent is the standard treatment for stage I lung adenocarcinoma. However, disease recurrence occurs in a third of patients. Prognostic biomarkers are needed to improve postoperative management. Here, we evaluate the utility of Homeobox A9 (HOXA9) promoter methylation, alone or in combination with Blood Vessel Invasion (BVI) assessment, for prognostic stratification of stage I lung adenocarcinoma patients.<h4>Materials and methods</h4>We developed a Dropl ...[more]
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