Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.
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ABSTRACT:
SUBMITTER: Lowe VJ
PROVIDER: S-EPMC6662599 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.
Lowe Val J VJ Lundt Emily S ES Albertson Sabrina M SM Przybelski Scott A SA Senjem Matthew L ML Parisi Joseph E JE Kantarci Kejal K Boeve Bradley B Jones David T DT Knopman David D Jack Clifford R CR Dickson Dennis W DW Petersen Ronald C RC Murray Melissa E ME
Alzheimer's & dementia : the journal of the Alzheimer's Association 20190604 7
<h4>Introduction</h4>Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential.<h4>Methods</h4>We compared the pathologic findings from a prospective autopsy cohort (n = 100) to Pittsburgh compound B PET (PiB-PET), <sup>18</sup>F-fluorodeoxyglucose PET (FDG-PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed.<h4>Results</h4>PiB-PET showed strong correlat ...[more]
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