Ontology highlight
ABSTRACT:
SUBMITTER: Nishimoto M
PROVIDER: S-EPMC6662713 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nishimoto Masazumi M Uranishi Kousuke K Asaka Masamitsu N MN Suzuki Ayumu A Mizuno Yosuke Y Hirasaki Masataka M Okuda Akihiko A
Scientific reports 20190729 1
YAP (also known as YAP1 or YAP65) is a transcriptional coactivator that interacts with a number of transcription factors including RUNX and TEAD and plays a pivotal role in controlling cell growth. YAP is classified as a proto-oncogene. However, the mechanism by which activated YAP induces cancerous changes is not well known. Here we demonstrate that overexpression of YAP in NIH3T3 cells was sufficient for inducing tumorigenic transformation of cells. Mechanistically, YAP exerts its function in ...[more]